Unable to set break point for debugging in Visual Studio

Getting “The breakpoint will not currently be hit. No symbols have been loaded for this document.” in Visual studio whenever you try to debug?
There are a million solutions out there and every time it is a different issue.

Here is one way of sorting things out in VS2012:

Go to Tools -> Options -> Debugging -> Symbols.
Hit Empty Symbol Cache and select All Modules Unless Excluded.

Possibly will need to restart VS. And should work.